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Avana 100 mg contains the active ingredient Avanafil and is used to treat erectile dysfunction (ED) in men. It's essential to be aware of potential drug interactions when taking Avana 100 mg to ensure safety and effectiveness. Here are some common drug interactions to consider:

Nitrates: Avanafil, the active ingredient in Avana, can potentiate the hypotensive effects of nitrates. Nitrates are commonly used to treat chest pain (angina) and include medications such as nitroglycerin. Combining Avana with nitrates can cause a sudden and significant drop in blood pressure, leading to dizziness, fainting, or even a heart attack. Therefore, Avana should not be taken with nitrates.

Alpha-blockers: Avanafil can also potentiate the hypotensive effects of alpha-blockers, which are used to treat high blood pressure (hypertension) and benign prostatic hyperplasia (BPH). Examples of alpha-blockers include doxazosin, tamsulosin, and terazosin. Combining Avana with alpha-blockers can cause a sudden drop in blood pressure, leading to dizziness, fainting, or other serious complications. It's important to discuss with your doctor if you are taking alpha-blockers before starting Avana.

Other PDE5 Inhibitors: Concurrent use of Avana with other phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra), may increase the risk of side effects, including hypotension (low blood pressure), priapism (prolonged erection), and other adverse effects. Therefore, it's generally not recommended to use Avana along with other PDE5 inhibitors.

Protease Inhibitors (Antiretroviral Medications): Protease inhibitors, which are used to treat HIV/AIDS, can increase the plasma levels of Avanafil. This can lead to an increased risk of Avana-related adverse effects. Therefore, caution should be exercised when Avana is used concomitantly with protease inhibitors. Your doctor may need to adjust the dosage of Avana if you are taking protease inhibitors.

CYP3A4 Inhibitors: Avanafil is metabolized primarily by the hepatic enzyme CYP3A4. Medications that inhibit CYP3A4 can increase the plasma levels of Avanafil, potentially leading to an increased risk of adverse effects. Examples of CYP3A4 inhibitors include ketoconazole, itraconazole, clarithromycin, erythromycin, ritonavir, and grapefruit juice. If you are taking any CYP3A4 inhibitors, your doctor may need to adjust the dosage of Avana accordingly.

Riociguat: Concurrent use of Avana with riociguat, a medication used to treat pulmonary arterial hypertension, is not recommended due to the potential for additive hypotensive effects.

Always inform your doctor about all the medications, supplements, and herbal products you are currently taking before starting Avana 100 mg or any other medication for erectile dysfunction.

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